Comparison of Raloxifene and Lasofoxifene - A Randomized, Blinded Study of These Drugs and Placebo on Bone Loss

Completed · Phase 3 · Has a placebo group

Conditions studied: Osteoporosis

In brief

To compare the effects of 2 years of lasofoxifene treatment with 2 years of raloxifene 60 mg/day use and 2 years of placebo use on bone mineral density (BMD) of the lumbar spine.

Key facts

Study ID

NCT00163137

Run by

Ligand Pharmaceuticals

People needed

540

Starts

2003-05-01

Expected to finish

2005-10-01

Last updated by the study team

2011-08-12

Who can join

Age: 48 and older, up to 75. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Postmenopausal women with low bone density (osteopenia) and screening labs, pelvic ultrasound, mammogram without significant findings

You may not qualify if…

• Presence of metabolic bone disease, fractures, blood clots, or recent cancer.
• Any use of selective estrogen receptor modulators, investigational drugs, or recent use of osteoporosis treatments, certain hormones, or medication for blood clots or seizures.

Where it is running

• Pfizer Investigational Site — Berkeley, California, United States
• Pfizer Investigational Site — La Jolla, California, United States
• Pfizer Investigational Site — La Jolla, California, United States
• Pfizer Investigational Site — Oakland, California, United States
• Pfizer Investigational Site — Oakland, California, United States
• Pfizer Investigational Site — Palo Alto, California, United States
• Pfizer Investigational Site — Poway, California, United States
• Pfizer Investigational Site — San Diego, California, United States
• Pfizer Investigational Site — San Diego, California, United States
• Pfizer Investigational Site — San Diego, California, United States
• Pfizer Investigational Site — Newark, Delaware, United States
• Pfizer Investigational Site — Brandon, Florida, United States
• Pfizer Investigational Site — Gainesville, Florida, United States
• Pfizer Investigational Site — Gainesville, Florida, United States
• Pfizer Investigational Site — Key Largo, Florida, United States
• Pfizer Investigational Site — Lake Worth, Florida, United States
• Pfizer Investigational Site — Leesburg, Florida, United States
• Pfizer Investigational Site — Miami, Florida, United States
• Pfizer Investigational Site — Miami, Florida, United States
• Pfizer Investigational Site — Miami, Florida, United States
• Pfizer Investigational Site — Tampa, Florida, United States
• Pfizer Investigational Site — Tampa, Florida, United States
• Pfizer Investigational Site — Tampa, Florida, United States
• Pfizer Investigational Site — West Palm Beach, Florida, United States
• Pfizer Investigational Site — Albany, California, United States

Full record on ClinicalTrials.gov

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