Alzheimer's in Long-Term Care--Treatment for Agitation

Completed · Not applicable · Has a placebo group

Conditions studied: Alzheimer Disease, Psychomotor Agitation

In brief

The purpose of this study is to see if a medication called prazosin is useful in the treatment of agitation and aggression in persons with Alzheimer's disease (AD) and other types of dementia in late life.

Key facts

Study ID

NCT00161473

Run by

University of Washington

People needed

24

Starts

2001-01-01

Expected to finish

2009-09-01

Last updated by the study team

2012-08-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• No age limit
• probable/possible Alzheimer's disease diagnosis
• disruptive agitated behaviors (e.g., irritability, aggression, uncooperativeness, pacing)
• no hypotension
• no concurrent use of alpha-1-blockers
• no delirium, schizophrenia, mania, psychotic symptoms.

You may not qualify if…

• Cardiovascular: unstable angina, recent myocardial infarction, second or third degree atrioventricular (AV) block, preexisting hypotension (systolic blood pressure less than 110) or orthostatic hypotension
• Other medical exclusions: chronic renal or hepatic failure, or any unstable medical condition
• Exclusionary medications: current treatment with prazosin, other alpha-1-blockers
• Current enrollment in a separate investigational drug trial
• Psychoactive medications: subjects may be psychoactive medication-free or be partial responders (by subjective assessment of referring health care professional) to one psychoactive medication from any of the following classes: antipsychotics, anticonvulsants, mood stabilizers, antidepressants, benzodiazepines, or buspirone. Partial response is defined as some improvement in agitated behavior but persistence of agitated behaviors severe enough to cause patient distress and/or difficulty with caregiving. Although not formally rated, this improvement is equivalent to a Clinical Global Impression of Change (CGIC) rating of no more than minimal improvement (improvement is noticed by not enough to improve patient function or caregiver's practical management of the patient).
• Psychiatric/behavioral: lifetime schizophrenia; current delirium, mania, depression, or uncontrolled persistent distressing psychotic symptoms (hallucinations, delusions), substance abuse, panic disorder, or any behavior which poses an immediate danger to patient or others or which results in the patient being too uncooperative to meet the requirements of study participation.

Where it is running

• Veterans Affairs Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.