Treatments for Psychogenic Nonepileptic Seizures (NES)

Completed · Phase 4 · Has a placebo group

Conditions studied: Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic

In brief

The investigators propose that treatment of the comorbid disorders (depression, anxiety, and impulsivity) with sertraline in patients with lone psychogenic nonepileptic seizures (NES), will result in a decreased number of NES. The purpose of this study is to provide pilot testing and data to inform the future randomized controlled trial based on the hypothesis.

Key facts

Study ID

NCT00159965

Run by

Rhode Island Hospital

People needed

38

Starts

2003-12-01

Expected to finish

2009-06-01

Last updated by the study team

2014-11-20

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Video electroencephalogram (vEEG) confirmed diagnosis of NES
• Have at least one nonepileptic seizure per month
• Comorbid diagnosis of either depression, anxiety, or post traumatic stress disorder (PTSD)
• Able to complete self report symptom scales
• Not receiving optimized antidepressant medication

You may not qualify if…

• Equivocal electroencephalogram (EEG) findings
• Current suicidality, litigation, or self-mutilation
• Using monoamine oxidase inhibitors (MAOIs), pimozide, or sumatriptan
• Allergy/sensitivity to sertraline
• Current alcohol/drug dependence
• Serious medical illness requiring current hospitalization

Where it is running

• Rhode Island Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.