Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer

Stopped early · Phase 1

Conditions studied: Carcinoma, Renal Cell

In brief

Patients with rectal cancer who are candidates for pre-operative radiation therapy may be enrolled in the Phase I, single center study. Patients will have a full blood count, biochemistry, urinalysis, and ECG for safety evaluation. Sequential cohorts of three patients will be given increasing doses of oral topotecan and fixed doses of concurrent radiation (45 Gy) over five weeks. The starting dose of oral topotecan is 0.25 mg/m2 to be concomitantly administered with radiation (45 Gy) x 5 days every week unless the radiation is interrupted for Holidays/Weekends or toxicity requiring treatment delays occurs. A total of 25 doses are planned.

Key facts

Study ID

NCT00158886

Run by

GlaxoSmithKline

People needed

26

Starts

2001-11-08

Expected to finish

2006-08-11

Last updated by the study team

2017-11-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with histologically confirmed rectal cancer.
• Candidates for preoperative radiotherapy.
• Primary tumor at least 3cm and clinical stage of T2, T3, or T4 and any N according to the Astler-Coller modification of the Dukes staging system.
• Eastern Cooperative Oncology Group (ECOG) performance status less than 2.
• Diagnosis of rectal cancer should be no more than 90 days from start of therapy.
• Evaluation at the H. Lee Moffitt Cancer Center.
• Recovery from prior surgery and life expectancy at least 3 months.

You may not qualify if…

• A primary tumor totally excised.
• Recurrent rectal cancer that failed initial treatment.
• Exposure to topotecan, infection, immunodeficiencies, conditions of the gastrointestinal (GI) tract which would affect absorption, medication that maintains motility/gastric emptying.
• Any concomitant malignancy within the last five years.
• Severe medical problems unrelated to the malignancy which would limit compliance with the study.
• Patients of child bearing potential.
• Not practicing adequate contraception.
• Patients who are pregnant or lactating.
• Use of an investigational drug within 30 days or 5 half-lives of the first dose.

Where it is running

• GSK Investigational Site — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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