Prescription Opioid Effects in Abusers Versus Non-Abusers

Completed · Phase 2 · Has a placebo group

Conditions studied: Opioid-Related Disorders, Substance-Related Disorders

In brief

The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.

Key facts

Study ID

NCT00158184

Run by

New York State Psychiatric Institute

People needed

27

Starts

2004-06-01

Expected to finish

2009-06-01

Last updated by the study team

2017-07-07

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• In good physical health
• Women reporting regular menstrual cycles lasting between 24 to 35 days
• Able to perform study procedures
• Normal body weight
• Use of opioids for medical purposes (cough, pain, or diarrhea) or recreational purposes at least twice in lifetime with no serious adverse effects
• Current opioid abuse, but not opioid dependence (drug abusers only)

You may not qualify if…

• On parole or probation
• Recently convicted of a crime of violence
• History of significant violent behavior
• Current Axis I psychopathology
• Significant Axis II disorder
• Pregnancy
• Women who have irregular menstrual cycles, or who are dysmenorrheic, amenorrheic, or menopausal
• Women who have been pregnant or breastfeeding within the past 6 months
• Women who have had a miscarriage or abortion within the past 6 months
• Women who meet DSM-IV criteria for premenstrual dysphoric disorder
• Women who report suffering from moderate to severe premenstrual symptoms
• Women seeking treatment for premenstrual problems
• Taking prescription or over-the-counter psychotropic medication
• History of chronic pain, or routinely uses over-the-counter analgesics (more than 4 days per month)
• Blood pressure greater than 150/90 mm Hg
• Reports of sensitivity, allergy, or contraindication to opioids
• Non-drug abusers:
• Current or lifetime history of substance abuse or dependence according to DSM-IV criteria (those requiring detoxification)
• Consumes more than 500 mg caffeine daily
• Seeking treatment for substance use

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.