Tadalafil in Subjects With Mild to Moderate Hypertension

Completed · Phase 2

Conditions studied: Hypertension

In brief

Purpose: The primary objective of this study is to evaluate the efficacy and safety of tadalafil when administered once daily at doses of 5 and 20 mg to adult subjects for 8 weeks with mild to moderate hypertension.

Key facts

Study ID

NCT00157326

Run by

Eli Lilly and Company

People needed

180

Starts

2005-09-01

Expected to finish

2006-06-01

Last updated by the study team

2007-10-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a documented medical history of hypertension.
• Have cuff seated diastolic blood pressure values greater than or equal to 95 and less than or equal to 104 mm at study entry
• Have a negative serum pregnancy test at the time of enrollment and agree to use two medically reliable methods of contraception until study completion, if female is of child-bearing potential, between menarche and 1 year post menopause and not surgically sterilized.
• Are able to comply with study procedures and visits

You may not qualify if…

• Have resistant hypertension or systolic hypertension.
• Are obese, defined as having body mass index (BMI) greater than or equal to 35.
• Are females who are pregnant or breast feeding.
• Have a history of severe renal insufficiency or significant thyroid, renal or hepatic disease.
• Have a glycosylated hemoglobin A1c (HbA1c) greater than or equal to 10% during the screening period.
• Have significant anemia.
• Have a significant or unstable cardiac history such as history of heart attack, unstable angina, or stroke within 6 months of study entry, history of angina that was treated with long- or short-acting nitrates within 90 days of study entry, history of coronary artery bypass graft surgery or cardiac angioplasty within 90 days of study entry, history of abnormal heart rhythms such as sick sinus syndrome or 2nd- or 3rd-degree AV block, chronic atrial fibrillation or recurrent atrial tachyarrhythmia, a history of recurrent ventricular tachycardia, or symptomatic bradycardia, a history of sudden cardiac arrest.
• Have symptomatic heart failure requiring treatment, or significant disease of the heart valves.
• Have been treated for severe asthma, bronchospasm, or COPD within 3 months of study entry.
• Have severe peripheral vascular disease.
• Have a documented diagnosis of sleep apnea.

Where it is running

• For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — Bothell, Washington, United States

Full record on ClinicalTrials.gov

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