MMR and Varicella Vaccine in Premature Infants
Completed
Conditions studied: Chickenpox, Rubella, Rubeola, Mumps
In brief
This research is designed to address the question, "Does the relative deficit in vaccine immunogenicity in extremely premature infants persist beyond the first 6 months of life?" We propose to measure the immunogenicity of varicella and mumps-measles-rubella vaccines in relatively healthy, 12-to-15 month-old children born at \<29 weeks gestation, when compared to full-term infants, as measured by the relevant viral serologies.
Key facts
- Study ID
- NCT00156559
- Run by
- University of Rochester
- People needed
- 32
- Starts
- 2004-01-01
- Expected to finish
- 2005-05-01
- Last updated by the study team
- 2015-09-17
Who can join
Age: 1 and older, up to 1. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects must meet all of the inclusion criteria to participate in this study.
- Premature infant < 29 weeks' gestation at birth or term infant >/= 37 weeks' gestation at birth.
- Postnatal age < 16 months, 0 days.
- Has not yet received MMR or varicella vaccines. (There are no restrictions on the administration of other vaccines at the time of MMR/varicella vaccination.)
- Parental permission.
- Agreement of primary care pediatrician/ health care provider.
- Receives primary pediatric care within an approximate 25-mile radius of the University of Rochester.
- Healthy status at enrollment.
You may not qualify if…
- Known immunodeficiency.
- Systemic corticosteroid therapy at the time of MMR/varicella vaccination.
- Requiring oxygen therapy.
- Clinically significant findings on review of medical history and physical exam determined by the investigator or sub-investigator to be sufficient for exclusion.
- Any condition determined by the investigator that would interfere with the evaluation of the vaccine or be a potential health risk to the subject.
Where it is running
- University of Rochester — Rochester, New York, United States
Full record on ClinicalTrials.gov
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