Genetic Predictors of Outcome in HCM Patients
Stopped early
Conditions studied: Hypertrophic Cardiomyopathy
In brief
This is a retrospective review of the data available on patients and their family members with HCM and prospective follow-up of this cohort for clinical outcome and diagnostic studies. Genetic samples are being examined in this cohort to determine whether certain to determine whether certain beta-AR polymorphisms as well as other common genetic polymorphisms are associated with different morphological features, such as LVH in patients with HCM and whether these polymorphisms influence the clinical course and outcome in patients with HCM. For that purpose, we will build a database with clinical information including serial echocardiographic measurements for patients with HCM that have regular follow up and test them for beta-AR polymorphisms as well as other common genetic polymorphisms and other known cardiac-related polymorphisms that can potentially contribute to the morphologic differences seen in patients with HCM.
Key facts
- Study ID
- NCT00156429
- Run by
- University of Pittsburgh
- People needed
- 98
- Starts
- 2009-04-22
- Expected to finish
- 2020-07-30
- Last updated by the study team
- 2020-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18+ years of age
- Diagnosed with HCM defined by the presence of left ventricular hypertrophy with minimal wall thickness >/= 15mm without the presence of hypertension or systemic disease that can account for the degree of hypertrophy.
You may not qualify if…
- Hypertension present prior to the diagnosis of HCM
- aortic stenosis with aortic valve area < 1cm2
- known systemic disease that can cause LVH, such as infiltrative diseases
- able and willing to provide informed consent
Where it is running
- UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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