Study to Eliminate Hib Carriage in Rural Alaska Native Villages
Completed · Phase 4
Conditions studied: Haemophilus Influenzae Type B, Carrier State
In brief
Hib disease rates in rural Alaska before introduction of HIb conjugate vaccine were among the highest in the world. Since vaccine introduction, rates have fallen by 90% but the disease has not been eliminated. This study is designed to test one possible means of eliminating Hib carriage and thus to eliminate person to person transmission and invasive disease. The objective of this study is to evaluate the effectiveness of community-wide use of Hib conjugate vaccine for eliminating oropharyngeal Hib carriage in rural Alaska villages. Secondary objectives include: * Determine risk factors for Hib OP carriage including demographic characteristics, and immunologic characteristics (antibody level and function). This will be accomplished through a case-control study described below. * Measure antibody response to Hib conjugate vaccine among adults who have not previously received Hib vaccine. This will be accomplished through a cohort study of participating adults in the vaccine intervention communities.
Key facts
- Study ID
- NCT00153556
- Run by
- Centers for Disease Control and Prevention
- People needed
- 3200
- Starts
- 2001-09-01
- Expected to finish
- 2003-11-01
- Last updated by the study team
- 2005-09-12
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All village residents are eligible for Hib colonization survey
- All residents of selected villages eligible for vaccine study except as noted below.
You may not qualify if…
- For receipt of vaccine:
- history of allergic reaction to Hib vaccine or components
- Age < 24 months and not due for Hib vaccine according to childhood immunization schedule
- Age > 24 months and have received HIb vaccine within past year
- Pregnant
Where it is running
- CDC Arctic Investigations Program — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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