Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease

Stopped early · Not applicable

Conditions studied: Inflammatory Bowel Disease (IBD)

In brief

The aim of this therapeutic trial is to compare the response of subjects with active IBD to daily intravenous dexamethasone versus the response to daily intravenous methylprednisolone.

Key facts

Study ID

NCT00152620

Run by

University of Chicago

People needed

40

Starts

2004-06-01

Expected to finish

2007-05-01

Last updated by the study team

2013-09-05

Who can join

Age: 6 and older, up to 19. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Parental informed consent
• Subjects 6 to 19 years of age with confirmed diagnosis of IBD (Crohn's disease, ulcerative colitis or indeterminate colitis), who on admission to the hospital have a PCDAI>15 or a Clinical-Activity Index for the Evaluation of Patients with Ulcerative Colitis of >10.
• Infectious causes (viruses, bacteria, parasites) have been ruled out.

You may not qualify if…

• Subjects in which the administration of corticosteroids would be contraindicated such as systemic or enteric infections diagnosed by stool analysis including culture, Clostridium Difficile toxin assay, rotavirus or adenovirus 40/41 antigens.
• Subjects with enterostomy or colostomy
• Subjects with one or more of the following conditions: unstable vital signs, acute abdomen, toxic megacolon, intestinal obstruction, intestinal perforation

Where it is running

• University of Chicago Comer Children's Hospital — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.