Orthotopic Liver Transplantation Using a Living Donor

Stopped early · Phase 4

Conditions studied: Liver Disease, Liver Neoplasms

In brief

The purpose of this study is to: determine the safety of donor right hepatic lobectomy as a procedure to provide a liver graft for living donor liver transplantation. study the regeneration of liver tissue by volumetric testing for both donor and recipient. assess if graft and patient survival with living donor transplantation is comparable to that of cadaveric donor transplantation.

Key facts

Study ID

NCT00152607

Run by

University of Chicago

People needed

20

Starts

2000-04-01

Expected to finish

2006-09-01

Last updated by the study team

2013-09-27

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-55
• No current or prior history of heart, lung or other medical problems.
• No history of liver disease.
• No history of malignancy, except limited basal cell carcinoma.
• ABO / HLA compatibility with the recipient.
• If female and premenopausal, a negative pregnancy test.
• Related to recipient either by blood or marriage and having a stable, long term, emotional relationship.
• The donor's body size and volumetric determination of liver mass by abdominal CT scan will indicate whether or not a donor is a suitable candidate for liver donation if the donor meets the other inclusion criteria. Favorable donors for the individual organs will be those with donor graft to recipient body dry weight ratios (GRBWR) of >0.7% and those with a ratio of graft volume to recipient's expected liver volume (GWRLW) of >35%.
• Satisfactory psychosocial evaluation. -

You may not qualify if…

• Recipient Exclusion Criteria:
• Pregnant or nursing females.
• Patients with significant concomitant infections.
• Patients who require multiple organ transplants.
• Significant pulmonary disease. If pulmonary disease is clinically suspected, diagnostic studies will be performed to exclude the presence of pulmonary hypertension (PA systolic pressure >40 mm Hg) or arterial saturation (Po2<60 mmHg, breathing room air).
• Patients at a higher than average perioperative risk secondary to severe decompensated liver disease or previous surgery (i.e., re-transplantation) or infections.

Where it is running

• The University of Chicago Hospitals — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.