Chemotherapy With CD133+ Select Autologous Hematopoietic Stem Cells for Children With Solid Tumors and Lymphomas

Completed · Not applicable

Conditions studied: Neuroblastoma, Central Nervous System Tumors, Lymphomas, Wilms Tumor

In brief

Studies have provided evidence that residual microscopic malignant cells in autologous bone marrow or blood stem cell grafts can contribute to posttransplant relapse. Researchers are currently exploring different methods in an attempt to purify or "purge" the stem cell product to minimize the risk of tumor contamination. The CD133+ antigen is a protein contained on or "expressed" on numerous cells in the human body including specific hematopoietic progenitor (blood forming) cells. However, this antigen is not expressed on certain cancer cells including neuroblastoma. A technique using the investigational CliniMACS cell sorting device has been developed in an effort to filter out only those stem cells that express this CD133+ antigen in order to infuse a hematopoietic stem cell product with no tumor contamination potential. The primary objective of this study is to establish safety of treating patients with a high dose chemotherapy regimen of Busulfan and Melphalan followed by autologous CD133+ hematopoietic stem cell support. Transplants recipients are expected to achieve engraftment as defined by an absolute neutrophil count of greater than or equal to 500/mm3 for three consecutive days by day 42-post infusion. Thus, safety of the treatment plan will be evaluated in terms of failure to engraft by this specific time period.

Key facts

Study ID

NCT00152126

Run by

St. Jude Children's Research Hospital

People needed

26

Starts

2003-08-01

Expected to finish

2009-02-01

Last updated by the study team

2009-02-13

Who can join

Age: any, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligibility will be determined separately for Part I and Part II of this study:
• Part I ( Part I Eligibility criteria (eligibility for undergoing apheresis procedure)
• Age ≤ 25 years at initial diagnosis.
• Must have one of the following diagnoses:
• High risk neuroblastoma
• Metastatic or recurrent retinoblastoma
• High risk rain tumors
• Recurrent or refractory Hodgkin disease
• Recurrent or advanced stage Wilms tumor
• Recurrent or metastatic sarcomas
• Recurrent or refractory non-Hodgkin lymphoma
• Desmoplastic small round cell tumor.
• Lansky or Karnofsky Performance Score ≥ 70.
• Creatinine ≤ 2.0 mg/dl.
• Direct bilirubin ≤ 2.0 mg/dl.
• SGPT ≤ 2 x upper limit of normal
• HIV testing
• Negative pregnancy test
• Patients with significant prior radiation therapy to the liver will be excluded.
• Part II eligibility criteria (criteria for transplantation of CD133 select stem cell product)
• Successfully completed Part I of protocol treatment plan and has the following available:
• Stored autologous bone marrow or peripheral blood stem cells (i.e. 2 x 106 unselected CD34+ cells/ kg PBSC or 1 x 106 CD34+ cells/ kg BM) for back up.
• Stored autologous bone marrow or peripheral blood stem cells (2 x 106 CD133+ cells/ kg PBSC or 2 x 106 CD133+ cells/ kg BM) for infusion.
• Forced vital capacity greater than or equal to 40% normal or pulse oximetry greater than or equal to 92% on room air.
• Lansky or Karnofsky Performance Score ≥ 70.

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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