Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life

Completed · Phase 4

Conditions studied: Acute Bacterial Sinusitis

In brief

This study is a comparison between two commonly used antibiotics (Cefdinir vs. Amoxicillin/Clavulanate) in patients with acute sinus infection, surveying quality of life. The hypothesis is that the two treatments would be at the least equivalent based on clinical outcome measures of improvement in quality of life.

Key facts

Study ID

NCT00147914

Run by

University of Chicago

People needed

100

Starts

2005-02-01

Expected to finish

2017-02-18

Last updated by the study team

2017-05-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female outpatient adults greater than 18 years old fulfilling the case definition for acute bacterial sinusitis
• Case definition includes clinical signs and symptoms, radiographic findings and collection of purulent material from the sinus

You may not qualify if…

• Symptoms less than 7 days and more than 3 weeks
• History of sinus surgery within 3 months
• History of frequent sinus infections (more than 2 episodes within the last 6 months)
• History of kidney and liver disease
• Pregnant and nursing women
• Pre-existing disease that could predispose to sinus infections (cystic fibrosis or nasal polyps
• Immunosuppressed patients
• History of allergy to either drug. Patients with a documented history of allergies to either penicillin or cephalosporins will be excluded.

Where it is running

• University of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.