Therapy for Pediatric Hodgkin Lymphoma

Completed · Phase 2

Conditions studied: Hodgkin Lymphoma

In brief

With the success of current chemotherapy for Hodgkin's disease, the goal of this protocol is to maintain the currently successful cure rate and reduce treatment related side effects and long term toxicity. The main purpose of this study is to estimate the event free survival of patients treated with risk-adapted therapy compared to historical controls.

Key facts

Study ID

NCT00145600

Run by

St. Jude Children's Research Hospital

People needed

296

Starts

2000-03-02

Expected to finish

2021-11-05

Last updated by the study team

2022-10-20

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible patients must have histologically confirmed previously untreated Hodgkin's disease (Patients receiving limited emergent RT or steroid therapy because of cardiopulmonary decompensation or spinal cord compression will be eligible for protocol enrollment).
• Patients must be 21 years of age or younger
• Ann Arbor stages IIB-IV
• No prior treatment.
• No pregnant or lactating women.
• Signed informed consent
• If re-evaluation of a patient's disease shows favorable risk features or intermediate risk features, the patient will be removed from the HOD99 study and consented to the respective HOD08 or HOD05 study.
• Inclusion: treatment of favorable risk features:
• Ann Arbor IA or IIA with:
• Non-bulky mediastinal disease (<33% mediastinal to thoracic ratio on chest x ray)
• Ann Arbor stage IA or IIA with any of the following features: (1) "E" lesions (s), (2) 3 or more nodal sites involved, (3) Bulky mediastinal adenopathy (mediastinal mass to thoracic cavity ratio 33% or greater by chest radiograph)
• Inclusion: unfavorable risk features:
• Stage must be classified as one of the following:
• Ann Arbor stage IIB, IIIB, or any IV

Where it is running

• Stanford University — Palo Alto, California, United States
• Maine Children's Cancer Program — Portland, Maine, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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