Patient-Centered Medication Adherence Intervention for Schizophrenia

Completed · Not applicable

Conditions studied: Schizophrenia

In brief

Efficacious antipsychotic medication treatments for schizophrenia are available; however , antipsychotic regimens frequently do not achieve their potential because of poor medication adherence. To date, medication adherence interventions have not been widely adopted or sustained in "real-world" practice settings. One reason for this is the substantial resource investment necessary to implement and sustain available interventions. In response to these problems, we developed a patient-centered adherence intervention based on patient-identified barriers, facilitators, and motivators (BFMs) for medication adherence. The intervention includes a BFM survey (checklist and preference weighting exercise to determine the patient's most important BFM) and a brief list of adherence enhancing suggestions (Options List) tailored to the patient-identified BFMs and compatible with CPRS. The long-term objective of this proposed research is to improve antipsychotic medication adherence and clinical outcomes for patients with schizophrenia using a cost-effective medication adherence intervention. The short-term objectives are to refine and test a patient-centered medication adherence intervention for VA patients with schizophrenia and specifically to: 1. Enhance the feasibility and acceptability of the BFM intervention by reducing the burden on patients and mental health providers through BFM checklist item reduction, provider intervention input, and patient intervention input. We hypothesize that our use of end-user input will result in at least 80% of intervention patients having documentation of a BFM intervention in CPRS. 2. Compare the effects of the BFM intervention versus usual care on changes in medication adherence and schizophrenia symptom severity. We hypothesize that the intervention will result in a) greater medication adherence and b) lower schizophrenia symptom severity than usual care. 3. Exploratory objective: compare the effects of the BFM intervention versus usual care on changes in patient health-related quality of life. We hypothesize that the intervention will result in greater health-related quality of life than usual care.

Key facts

Study ID

NCT00144027

Run by

US Department of Veterans Affairs

People needed

75

Starts

2004-12-01

Expected to finish

2009-07-01

Last updated by the study team

2015-04-24

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• medical chart diagnosis of schizophrenia or schizoaffective disorder;
• currently prescribed outpatient antipsychotic medication (oral or depot);
• patient must have adequate capacity to provide informed consent, understand the nature of the study, and sign an informed consent document.

You may not qualify if…

• significant cognitive impairment as indicated by a score > 10 on the Blessed Orientation-Memory-Concentration (BOMC) Test.

Where it is running

• Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR — No. Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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