Tramadol to Reduce Opioid Withdrawal Symptoms

Completed · Phase 2

Conditions studied: Opioid-Related Disorders

In brief

Individuals with opioid addiction often experience serious withdrawal symptoms that may make relapse unavoidable. Tramadol, a medication that is currently used to treat pain caused by chronic conditions such as cancer or joint pain, may also be effective at reducing opioid withdrawal symptoms. This study will evaluate the effectiveness of tramadol at reducing withdrawal symptoms in individuals addicted to opioid drugs.

Key facts

Study ID

NCT00142896

Run by

National Institute on Drug Abuse (NIDA)

People needed

16

Starts

2005-02-01

Expected to finish

2005-12-01

Last updated by the study team

2017-01-12

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets DSM-IV diagnostic criteria for opioid dependence
• Is in good physical health
• Qualifies for treatment with opioid agonist therapy (e.g., methadone)
• If female, must have a negative pregnancy test prior to study entry

You may not qualify if…

• Evidence of significant medical illness (e.g., insulin dependent diabetes mellitus)
• Evidence of significant psychiatric illness (e.g., schizophrenia)
• Currently seeking treatment for substance abuse
• Pregnant or breastfeeding

Where it is running

• Johns Hopkins University (BPRU) Bayview Campus — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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