Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts

Completed · Not applicable

Conditions studied: Cocaine-Related Disorders, Opioid-Related Disorders

In brief

Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Fluoxetine, a medication that is currently used to treat depression and anxiety disorders, may also be effective at diminishing cocaine use in individuals with severe cocaine addiction. This study will evaluate the effectiveness of fluoxetine at reducing cocaine use in individuals addicted to cocaine and opioids who are concurrently receiving methadone treatment.

Key facts

Study ID

NCT00142779

Run by

National Institute on Drug Abuse (NIDA)

People needed

220

Starts

2001-04-01

Expected to finish

2006-03-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently dependent on opioids
• Currently dependent on cocaine
• Eligible to receive methadone maintenance treatment

You may not qualify if…

• Current significant medical or psychiatric illness
• Current use of a specific serotonin reuptake inhibitor (SSRI)
• History of allergy to SSRI medications

Where it is running

• Johns Hopkins University School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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