Opioid Agonist and Antagonist Effects on Opioid Dependence

Stopped early · Phase 2

Conditions studied: Opioid-Related Disorders

In brief

The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different levels of physical opioid dependence.

Key facts

Study ID

NCT00142727

Run by

National Institute on Drug Abuse (NIDA)

People needed

16

Starts

2004-01-01

Expected to finish

2006-02-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Active opioid dependence
• Qualifies for opioid agonist treatment (e.g., methadone or buprenorphine)
• Fulfills DSM-IV diagnostic criteria for opioid dependence

You may not qualify if…

• Significant medical problems, including insulin dependent diabetes mellitus
• Non-substance use psychiatric disorders (e.g., schizophrenia)
• Currently seeking treatment for substance abuse

Where it is running

• Johns Hopkins University (BPRU) Bayview Campus — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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