Ancrod (Viprinex™) for the Treatment of Acute, Ischemic Stroke

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Stroke, Cerebral Ischemia, Brain Infarction

In brief

The primary purpose of this study is to determine whether a brief intravenous infusion of ancrod started within 6 hours of stroke onset improves functional outcome at 3 months.

Key facts

Study ID

NCT00141011

Run by

Neurobiological Technologies

People needed

277

Starts

2005-09-01

Expected to finish

2008-12-01

Last updated by the study team

2009-12-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute, ischemic stroke with first symptoms within 6 hours of beginning treatment
• Baseline NIHSS > 5

You may not qualify if…

• No intracranial, extravascular blood on CT
• Hypertension (systolic > 185; diastolic > 105)
• Baseline fibrinogen level < 100 mg/dL
• Thrombocytopenia (< 100,000 / mm3)
• Recent (< 3 days) or anticipated (< 5 days) use of a thrombolytic agent
• Recent (< 14 days) or anticipated surgery

Where it is running

• Sparks Regional Medical Center — Fort Smith, Arkansas, United States
• Loma Linda University School of Medicine — Loma Linda, California, United States
• Santa Monica - UCLA Medical Center — Los Angeles, California, United States
• UCLA Medical Center — Los Angeles, California, United States
• Hoag Memorial Hospital — Newport Beach, California, United States
• The Neurology Center: Tri-City Medical Center — Oceanside, California, United States
• Shasta Regional Medical — Redding, California, United States
• Bridgeport Hospital — Bridgeport, Connecticut, United States
• Neurologic Consultants, P.A. — Fort Lauderdale, Florida, United States
• Shands Jacksonville / University of Florida — Jacksonville, Florida, United States
• Ocala Neurodiagnostic Center — Ocala, Florida, United States
• Florida Hospital Neuroloscience Institute — Orlando, Florida, United States
• Fawcett Memorial Hospital — Port Charlotte, Florida, United States
• Peace River Regional Medical Center — Port Charlotte, Florida, United States
• Tallahassee Memorial Healthcare, Inc. — Tallahassee, Florida, United States
• The Queens Medical Center, Neuroscience Institute — Honolulu, Hawaii, United States
• Mercy Hospital — Chicago, Illinois, United States
• Elkhart Clinic, LLC - Neurology — Elkhart, Indiana, United States
• Fort Wayne Neurological Center — Fort Wayne, Indiana, United States
• Parkview Research Center — Fort Wayne, Indiana, United States
• Sinai Hospital of Baltimore — Baltimore, Maryland, United States
• Baystate Medical Center — Springfield, Massachusetts, United States
• Wayne State University — Detroit, Michigan, United States
• St. Mary's Duluth Clinic — Duluth, Minnesota, United States
• Mayo Clinic Hospital / Arizona — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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