NO Need to Ventilate: A Trial of Non-invasive Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn

Completed · Not applicable

Conditions studied: Pulmonary Hypertension

In brief

The primary objective of the trial is to determine the feasibility and clinical safety and efficacy of non-invasive inhaled nitric oxide in infants with PPHN without significant pulmonary +-parenchymal disease who would normally receive inhaled nitric oxide only after placement of a tracheal tube and the institution of mechanical ventilation.

Key facts

Study ID

NCT00139217

Run by

Emory University

People needed

400

Starts

2005-08-01

Expected to finish

2007-09-01

Last updated by the study team

2014-05-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newborn infants >/= 34 weeks with clinical or echocardiographic evidence of PPHN with a PaO2 < 100 of Fio2 0.8 who are not mechanically ventilated

You may not qualify if…

• Infants with significant lung disease
• Inability to sustain spontaneous respirations
• Lethal congenital anomalies
• Severe birth asphyxia

Where it is running

• Emory University affiliated newborn intensive care units — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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