Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair

Completed · Phase 4 · Has a placebo group

Conditions studied: Lung Disease

In brief

The purpose of this study is to study the effects of Xolair using non-invasive techniques from the expired gas of patients with moderate to severe allergic asthma.

Key facts

Study ID

NCT00139152

Run by

Creighton University

People needed

65

Starts

2005-09-01

Expected to finish

2009-12-01

Last updated by the study team

2014-01-07

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• On medium to high dose inhaled corticosteroids either with or without a long acting beta agonist
• Baseline IgE 30-700 IU/mL
• Exhaled nitric oxide greater than 13 ppb
• Positive skin test to at least one of the following perennial allergens: cat, dog, dust mite, cockroach
• Stable asthma at the time of enrollment

You may not qualify if…

• Concurrent diseases/conditions, history of other diseases/conditions, with clinically significant uncontrolled systemic disease or a history of such disease (eg, infection, hematological, renal, hepatic, coronary heart disease or other cardiovascular disease, endocrinological, or gastrointestinal disease) within previous 3 months
• Upper or lower respiratory tract infection within 6 weeks of screening visit
• Elevated IgE level other than atopy
• Known sensitivity to Xolair
• < 3 months of stable immunotherapy
• Smokers
• Pregnant/nursing women
• Women of childbearing potential who are not practicing medically approved contraceptive methods (eg, oral, subcutaneous, mechanical, or surgical contraception) including abstinence
• Patients who currently hav diagnosed cancer, are currently being investigated for possible cancer or who have any history of cancer
• Known sensitivity to study drug or class of study drugs
• Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study
• Use of any other investigational agent in the last 30 days.

Where it is running

• Creighton University Division of Allergy & Immunology — Omaha, Nebraska, United States
• Albany Medical College — Albany, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.