Immunogenicity Study of an Inactivated Hepatitis A Vaccine in Infants and Young Children
Completed · Phase 4
Conditions studied: Hepatitis A
In brief
Infants born to immune mothers and therefore having passively-transferred maternal antibody (PMA) to hepatitis A virus (HAV) have a blunted immune response to hepatitis A vaccine. We compared the immunogenicity of hepatitis A vaccine among infants with and without PMA, vaccinated on different schedules. We found that when vaccination is begun at or after 12 months of age, there was no difference in the immune response to the vaccine between infants born to immune vs. susceptible mothers.
Key facts
- Study ID
- NCT00139113
- Run by
- Centers for Disease Control and Prevention
- People needed
- 248
- Starts
- 1996-09-01
- Expected to finish
- 2001-06-01
- Last updated by the study team
- 2024-08-20
Who can join
Age: 1 and older, up to 25. Sex: any. Healthy volunteers: accepted.
Where it is running
- Anchorage Neighborhood Health Center — Anchorage, Alaska, United States
- Alaska Native Medical Center — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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