Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors
Completed · Phase 1
Conditions studied: Brain and Central Nervous System Tumors, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
RATIONALE: Drugs used in chemotherapy, such as temozolomide, vincristine, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when given together with temozolomide and vincristine in treating young patients with refractory solid tumors.
Key facts
- Study ID
- NCT00138216
- Run by
- Children's Oncology Group
- People needed
- 42
- Starts
- 2005-10-01
- Expected to finish
- 2011-01-01
- Last updated by the study team
- 2023-10-02
Who can join
Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham — Birmingham, Alabama, United States
- Children's Hospital of Orange County — Orange, California, United States
- Stanford Cancer Center — Stanford, California, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Masonic Cancer Center at University of Minnesota — Minneapolis, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
- SUNY Upstate Medical University Hospital — Syracuse, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Oregon Health and Science University Cancer Institute — Portland, Oregon, United States
- Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas — Dallas, Texas, United States
- Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
- Hospital for Sick Children — Toronto, Ontario, Canada
- Hopital Sainte Justine — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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