Isotretinoin, Interferon Alpha-2b, and Paclitaxel in Stage IV, Recurrent, or Persistent Cervical Cancer

Stopped early · Phase 2

Conditions studied: Cervical Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Sometimes when chemotherapy is given, it does not stop the growth of tumor cells. The tumor is said to be resistant to chemotherapy. Giving isotretinoin and interferon alpha-2b together with paclitaxel may reduce drug resistance and allow the tumor cells to be killed. PURPOSE: This phase II trial is studying how well giving isotretinoin and interferon alpha-2b together with paclitaxel works in treating patients with stage IV, recurrent, or persistent cervical cancer.

Key facts

Study ID

NCT00138151

Run by

University of Medicine and Dentistry of New Jersey

People needed

33

Starts

2001-03-01

Expected to finish

2010-11-01

Last updated by the study team

2013-11-20

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Cancer Institute of New Jersey at Hamilton — Hamilton, New Jersey, United States
• Carol G. Simon Cancer Center at Morristown Memorial Hospital — Morristown, New Jersey, United States
• Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
• Saint Peter's University Hospital — New Brunswick, New Jersey, United States
• UMDNJ University Hospital — Newark, New Jersey, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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