Avastin and Taxotere for Esophagogastric Cancer

Completed · Phase 2

Conditions studied: Esophageal Cancer, Gastric Cancer

In brief

The purpose of this study is to determine what effects (good and bad) bevacizumab (Avastin) and docetaxel (Taxotere), used in combination, have on metastatic gastric and esophageal cancer.

Key facts

Study ID

NCT00137813

Run by

Dana-Farber Cancer Institute

People needed

42

Starts

2004-08-01

Expected to finish

2009-09-01

Last updated by the study team

2018-11-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed, unresectable or metastatic stage IV esophageal or gastric carcinoma
• Measurable disease greater than or equal to 1cm by spiral computed tomography (CT) scan or greater than or equal to 2cm by other radiographic technique
• ECOG performance status 0-2
• One prior chemotherapy for metastatic disease permitted
• White blood cell count greater than or equal to 3,000/mm
• Absolute neutrophil count greater than or equal to 1,500/mm3
• Platelet count greater than or equal to 100,000/mm3
• Hemoglobin greater than or equal to 8.0g/dl
• Creatinine less than 2.0mg/dL
• Total bilirubin less than 1.9mg/dL

You may not qualify if…

• Pregnant or lactating women
• History or evidence of central nervous system (CNS) disease
• Other active malignancies other than non-melanoma skin cancer or in-situ cervical cancer
• History of severe hypersensitivity to docetaxel, bevacizumab or drugs formulated with polysorbate 80.
• Current, recent or planned treatment with standard chemotherapy, radiation therapy or another experimental therapy.
• History of other disease or metabolic dysfunction.
• Serious, non-healing wound, ulcer, or bone fracture.

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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