Bevacizumab in Combination With Temozolomide in Patients With Neuroendocrine Tumors
Completed · Phase 2
Conditions studied: Neuroendocrine Tumors
In brief
The purpose of this study is to determine what effects (good and bad) bevacizumab and temozolomide have on patients with neuroendocrine tumors.
Key facts
- Study ID
- NCT00137774
- Run by
- Dana-Farber Cancer Institute
- People needed
- 34
- Starts
- 2004-11-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2013-04-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically documented locally unresectable or metastatic neuroendocrine tumor excluding small cell carcinoma
- Measurable disease > 1cm by spiral computed tomography (CT) or > 2cm by other radiographic technique
- ECOG performance status of 0-2
- Life expectancy of > 12 weeks
- Prior treatment with chemotherapy is allowed
- Total bilirubin < 2.0mg/dl
- AST < 5x upper limit of normal (ULN)
- Serum creatinine < 2.0mg/dl
- Absolute neutrophil count > 1,000/mm3
- Platelets > 100,000/mm3
- International Normalized Ratio (INR) < 1.5
You may not qualify if…
- Prior treatment with temozolomide, decarbazine or bevacizumab
- Clinically apparent central nervous system metastases or carcinomatous meningitis
- Clinically significant cardiovascular disease
- Major surgery, open biopsy, or significant traumatic injury within 28 days
- Pregnant or breast-feeding women
- Chronic, daily treatment with aspirin or nonsteroidal anti-inflammatory medication
- Serious, nonhealing wound, ulcer or bone fracture
- Evidence of bleeding diathesis or coagulopathy
- History of other disease or metabolic dysfunction
Where it is running
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Dana-Farber Cancer Insitute — Boston, Massachusetts, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.