Facilitating the Adoption of Evidence-Based Depression Management in Substance Use Treatment Programs

Completed · Phase 4

Conditions studied: Mood Disorders, Substance-Related Disorders

In brief

Comorbid depression has been consistently linked to worse outcomes for patients in substance abuse treatment programs. Practice guidelines recommend pharmacotherapy for comorbid depression if symptoms persist after a 4-week "wash-out" period for detoxification (e.g., Veterans Health Administration; American Psychiatric Association). Medications may be considered earlier if a patient has current symptoms and a history of major depressive disorder (MDD) during periods of sobriety. Current efficacy data suggest that antidepressant medication can improve both depression and substance use outcomes among comorbid patients Guideline-concordant use of antidepressant medication for persons with comorbid substance use and depressive disorders, however, is not routine in many VA substance abuse treatment settings.

Key facts

Study ID

NCT00137306

Run by

US Department of Veterans Affairs

People needed

300

Starts

2004-01-01

Expected to finish

2006-10-01

Last updated by the study team

2015-04-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Programs: VA's offering residential or intensive outpatient treatment for substance-related disorders in VISN 16 Patients: Veterans in residential or intensive outpatient treatment for substance-related disorders; positive screen for non-substance-induced depressive disorder

Where it is running

• Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR — No. Little Rock, Arkansas, United States
• Southeast Louisiana Veterans Health Care System, New Orleans, LA — New Orleans, Louisiana, United States
• VA Gulf Coast Veterans Health Care System — Biloxi, Mississippi, United States
• G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS — Jackson, Mississippi, United States
• Oklahoma City, OK — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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