Post Burn Pruritus Study in Patients Undergoing Wound Healing

Completed · Not applicable

Conditions studied: Itching

In brief

The purpose of this study is to see if a drug called ondansetron (Zofran) controls itching from healing burn wounds as well or better than the usual drug used, diphenhydramine (Benadryl).

Key facts

Study ID

NCT00137202

Run by

United States Army Institute of Surgical Research

People needed

36

Starts

2005-06-01

Expected to finish

2006-05-01

Last updated by the study team

2008-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females; 18 years or older.
• Seen in the United States Army Institute of Surgical Research (USAISR) Burn Clinic with healing burn wounds of any percent (%) of total body surface area (TBSA) causing pruritus
• Stable medical condition
• Negative pregnancy test and not nursing
• Able to indicate status of pruritus on a numeric scale
• Able to understand and read English

You may not qualify if…

• Unstable medical condition as determined by attending burn surgeon
• Prisoner
• History of allergic reaction to serotonin inhibitors or diphenhydramine
• Pregnant or lactating
• Unable to verbalize pruritus intensity scale
• Unable to understand or read English

Where it is running

• US Army Institute of Surgical Research — Fort Sam Houston, Texas, United States

Full record on ClinicalTrials.gov

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