Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.

Completed · Phase 3

Conditions studied: Hypercholesterolemia, Familial, Hyperlipidemia

In brief

The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To look at ultrasound images taken in the carotid arteries and to look at various lipids in the blood of people with heterozygous familial hypercholesterolemia

Key facts

Study ID

NCT00136981

Run by

Pfizer

People needed

800

Starts

2003-12-01

Expected to finish

2006-11-01

Last updated by the study team

2015-04-22

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Heterozygous Familial Hypercholesterolemia
• At least 18 years of age

You may not qualify if…

• Women who are pregnant or lactating, or planning to become pregnant.
• Subjects with a clinically indicated need for statin (HMG-CoA reductase inhibitor) therapy other than atorvastatin or other concomitant therapy with known lipid altering effects on LDL-C and HDL-C including fibrates and nicotinic acid (high doses)
• Subjects taking any drugs known to be associated with an increased risk of myositis in combination with HMG-CoA reductase inhibitors
• Subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluationof response, or render unlikely that the subject would complete the study

Where it is running

• Pfizer Investigational Site — Hartford, Connecticut, United States
• Pfizer Investigational Site — Boston, Massachusetts, United States
• Pfizer Investigational Site — Minneapolis, Minnesota, United States
• Pfizer Investigational Site — New York, New York, United States
• Pfizer Investigational Site — Houston, Texas, United States
• Pfizer Investigational Site — Salt Lake City, Utah, United States
• Pfizer Investigational Site — Seattle, Washington, United States
• Pfizer Investigational Site — Vancouver, British Columbia, Canada
• Pfizer Investigational Site — Winnipeg, Manitoba, Canada
• Pfizer Investigational Site — Chicoutimi, Quebec, Canada
• Pfizer Investigational Site — Montreal, Quebec, Canada
• Pfizer Investigational Site — Québec, Quebec, Canada
• Pfizer Investigational Site — Prague, Czechia
• Pfizer Investigational Site — Kuopio, Finland
• Pfizer Investigational Site — OYS, Finland
• Pfizer Investigational Site — Paris, France
• Pfizer Investigational Site — Toul, France
• Pfizer Investigational Site — Brescia, Italy
• Pfizer Investigational Site — Pavia, Italy
• Pfizer Investigational Site — Alkmaar, Netherlands
• Pfizer Investigational Site — Amsterdam, Netherlands
• Pfizer Investigational Site — Delft, Netherlands
• Pfizer Investigational Site — Goes, Netherlands
• Pfizer Investigational Site — Groningen, Netherlands
• Pfizer Investigational Site — Hoorn, Netherlands

Full record on ClinicalTrials.gov

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