SB-743921 In Patients With Solid Tumors

Completed · Phase 1

Conditions studied: Solid Tumor Cancer

In brief

The purpose of this study is to find a dose of SB-743921 in adult patients with solid tumors or lymphoma who have progressed on standard therapy or who have relapsed. SB-743921 is dosed by 1-hour intravenous infusion every 3 weeks. A patient may continue to receive treatment as long as they are benefiting from the treatment. Blood samples will be taken at specific times to measure the amount of the drug in your body at specific times after the drug is given. Blood samples will also be taken for lab tests such as complete blood counts and clinical chemistries. Physical exams will be performed before each treatment with SB-743921. During the treatment phase, the patients will undergo regular assessments for safety and clinical response.

Key facts

Study ID

NCT00136513

Run by

GlaxoSmithKline

People needed

30

Starts

2004-04-01

Last updated by the study team

2008-10-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed diagnosis of: a) Advanced solid tumor malignancy that is not responsive to standard therapies or for which there is no standard therapy; OR b) B-cell or T-cell lymphoma (excluding HIV-associated lymphoma) that has relapsed or is refractory after prior chemotherapy or radiotherapy and autologous or allogeneic bone marrow transplantation (if appropriate) AND/OR for which salvage chemotherapy, radiotherapy, or bone marrow transplantation is not indicated or has been refused by the patient.
• ECOG (Eastern Cooperative Oncology Group) Performance Status of 0-2.

You may not qualify if…

• Pre-existing hemolytic anemia.
• Pre-existing peripheral neuropathy greater than or equal grade 2.
• Absolute neutrophil count less than 1,500/mm3.
• Platelets less than 100,000/mm3.
• Hemoglobin less than 9 g/dL.
• Total bilirubin greater than1.5 mg/dL.
• AST/ALT greater than 2.5 X upper limit of normal.
• Creatinine clearance less than or equal to 60 mL/min.

Where it is running

• GSK Investigational Site — Pittsburgh, Pennsylvania, United States
• GSK Investigational Site — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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