Continuous Femoral Nerve Block Following Total Knee Replacement

Completed · Not applicable

Conditions studied: Pain

In brief

The purpose of this study is to determine if putting local anesthetic-or numbing medication-through a tiny tube next to the nerves that go to the knee will improve pain control during physical therapy, and ultimately improve the results of surgery. It will also determine if patients having knee replacement surgery may receive the same or better pain control at home compared with staying in the hospital, and if this improves their experience following surgery.

Key facts

Study ID

NCT00135889

Run by

National Institute of General Medical Sciences (NIGMS)

People needed

50

Starts

2005-01-01

Expected to finish

2008-07-01

Last updated by the study team

2009-10-08

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing unilateral, primary total knee arthropathy (TKA)
• 18-80 years of age
• Be able to understand the possible local anesthetic-related complications, study protocol, and care of the catheter and infusion pump system and are already planning on having a perineural catheter placed for postoperative analgesia

You may not qualify if…

• Any contraindication to femoral block/catheter
• Any comorbidity which results in moderate or severe functional limitation (American Society of Anesthesiologists [ASA] physical status >2)
• Baseline oxygen saturation < 96% on room air
• Known hepatic or renal insufficiency (creatinine level > 1.5 mg/dL)
• Allergy to study medications (other than nonsteroidal anti-inflammatory agents [NSAIDs] and acetaminophen)
• Inability to communicate with the authors
• Morbid obesity (body mass index [BMI]>40 kg/m2)
• History of opioid abuse or chronic regular opioid use (use within the 2 weeks prior to surgery and duration of use > 4 weeks)

Where it is running

• University of California San Diego — La Jolla, California, United States
• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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