Effectiveness of Bupropion Combined With Behavioral Therapy for Treating Methamphetamine Dependence - 2

Completed · Phase 2 · Has a placebo group

Conditions studied: Methamphetamine

In brief

Methamphetamine is an addictive stimulant drug that strongly activates certain parts of the brain. The purpose of this study is to determine the effectiveness of bupropion in combination with behavioral therapy for the treatment of methamphetamine addiction.

Key facts

Study ID

NCT00135785

Run by

National Institute on Drug Abuse (NIDA)

People needed

73

Starts

2005-10-01

Expected to finish

2007-05-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Meets DSM-IV criteria for methamphetamine dependence
• Females must use an effective method of contraception

You may not qualify if…

• History of or current medical condition that might interfere with safe participation, such as active tuberculosis, unstable heart or liver disease, unstable diabetes, symptomatic AIDS (non-symptomatic HIV infection is not an exclusion), or greater than 8 times the upper limit of normal in liver screening function tests (SGOT or SGPT)
• Current neurological disorder (e.g., organic brain disease, dementia)
• Major psychiatric disorder unrelated to substance abuse, such as schizophrenia or bipolar disorder (assessed by the SCID and a medical history)
• Suicide attempt within the month prior to enrollment and/or currently suicidal (assessed by the SCID and the BDI II)
• Currently on prescription medication that might interact with the study drug
• Currently dependent on cocaine, opiates, alcohol, or benzodiazepines, as defined by DSM-IV-TR criteria
• History of alcohol dependence within past three years
• History of seizure disorders
• History of anorexia or bulimia
• Current hypertension uncontrolled by medication
• History of sensitivity to bupropion
• Pregnant or breastfeeding

Where it is running

• UCLA Medical Center — Los Angeles, California, United States
• Rancho Cucamonga Clinic — Rancho Cucamonga, California, United States

Full record on ClinicalTrials.gov

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