Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2

Completed

Conditions studied: Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder

In brief

Nicotine dependence is very common among individuals with schizophrenia and schizoaffective disorder. Cotinine is a chemical that is made by the body from nicotine. Measuring levels of nicotine and cotinine is an accurate way to determine how much cigarette smoke enters a person's body. The purpose of this study is to measure nicotine and cotinine levels in smokers with schizophrenia or schizoaffective disorder to determine if such individuals absorb more nicotine per cigarette than smokers without schizophrenia-related disorders.

Key facts

Study ID

NCT00135772

Run by

National Institute on Drug Abuse (NIDA)

People needed

100

Starts

2003-10-01

Expected to finish

2004-07-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Meets DSM-IV diagnostic criteria for nicotine dependence and possibly schizophrenia or schizoaffective disorder
• Stable on current antipsychotic regimen(s) for participants with schizophrenia or schizoaffective disorder

You may not qualify if…

• At serious risk of suicide, including recent suicidal behavior or attempt within the thirty days prior to study entry
• Current use of clonidine, bupropion, or any other nicotine products (including nicotine patch, gum, inhaler, lozenge or nasal spray)

Where it is running

• UMDNJ - Robert Wood Johnson Medical School — Piscataway, New Jersey, United States

Full record on ClinicalTrials.gov

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