Addition of Naltrexone to Methadone Taper

Completed · Phase 2 · Has a placebo group

Conditions studied: Heroin Dependence, Opioid-Related Disorders, Substance-Related Disorders

In brief

There is a continuing search for more effective opiate detoxification treatments. This study's purpose is to investigate the effects of adding very low doses of naltrexone to a methadone tapering treatment in opioid dependent individuals.

Key facts

Study ID

NCT00135759

Run by

National Institute on Drug Abuse (NIDA)

People needed

174

Starts

2005-04-01

Expected to finish

2006-07-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current DSM-IV diagnosis of opiate dependence
• Reads and understands English

You may not qualify if…

• Serious medical disorders (e.g., uncontrolled hypertension, acute or chronic active hepatitis, kidney failure, uncontrolled diabetes)
• Psychiatric conditions that require intensive services (e.g., depression with suicidal ideation, psychosis)
• Mental retardation or other disorder that might limit ability to give informed consent
• Pregnant

Where it is running

• Duke University — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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