A Study of Prevalence of the I50L Mutation When ATV Treated Patients Fail the Regimen

Completed

Conditions studied: HIV Infections

In brief

The purpose of this study is to find out the frequency of the I50L substitution among patients experiencing treatment failure on an atazanavir-containing regimen.

Key facts

Study ID

NCT00135447

Run by

Bristol-Myers Squibb

People needed

5000

Starts

2004-09-01

Expected to finish

2009-09-01

Last updated by the study team

2011-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Atazanavir - containing antiretroviral regimen
• Confirmed virologic failure defined as either:
• HIV RNA by PCR greater than or equal to 1000 copies/mL after achieving a value of <400 copies/mL on at least 2 consecutive measurements or
• HIV RNA greater than or equal to 1000 copies/mL after 24 weeks of continuous therapy
• At least 18 years old

You may not qualify if…

• Unable to give informed consent
• Prisoners or subjects involuntarily incarcerated for treatment of psychiatric or physical illness

Where it is running

• Vista Medical Partners — Beverly Hills, California, United States
• AIDS Healthcare Foundation — Beverly Hills, California, United States
• AltaMed Health Services Corporation — Los Angeles, California, United States
• Kaiser Permanente — Los Angeles, California, United States
• Synergy Hematology and Oncology Medical Associates — Los Angeles, California, United States
• Orange Coast Medical Group — Newport Beach, California, United States
• Alameda County Medical Center — Oakland, California, United States
• East Bay AIDS Center — Oakland, California, United States
• Desert Medical Group — Palm Springs, California, United States
• Martin M. Mass, MD — San Francisco, California, United States
• Wellspring Medical Group — San Francisco, California, United States
• San Mateo Medical Center — San Mateo, California, United States
• Stanford University Medical Center — Stanford, California, United States
• Denver Public Health — Denver, Colorado, United States
• Local Institution — Denver, Colorado, United States
• Dupont Circle Physicians Group, P.C. — Washington D.C., District of Columbia, United States
• South Florida Clinical Research — Atlantis, Florida, United States
• Daniel A. Warner, MD, PA — Daytona Beach, Florida, United States
• Gary J. Richmond, MD, PA — Fort Lauderdale, Florida, United States
• Biogenomx Research Institute, LLC/CHC1-AP — Hollywood, Florida, United States
• AIDS Healthcare Foundation — Jacksonville, Florida, United States
• Steinhart Medical Associates — Miami, Florida, United States
• University of Miami School of Medicine — Miami, Florida, United States
• Care Resource, Inc. — Miami, Florida, United States
• Local Institution — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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