S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy
Completed · Phase 3 · Has a placebo group
Conditions studied: Metastatic Cancer, Prostate Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as docetaxel, prednisone, and atrasentan work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether docetaxel, prednisone, and atrasentan are more effective than docetaxel and prednisone in treating prostate cancer. PURPOSE: This randomized phase III trial is studying docetaxel, prednisone, and atrasentan to see how well they work compared to docetaxel and prednisone in treating patients with stage IV prostate cancer and bone metastases that did not respond to previous hormone therapy.
Key facts
- Study ID
- NCT00134056
- Run by
- SWOG Cancer Research Network
- People needed
- 1038
- Starts
- 2006-08-01
- Expected to finish
- 2016-02-01
- Last updated by the study team
- 2021-10-27
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
Where it is running
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
- Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
- Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
- East Bay Radiation Oncology Center — Castro Valley, California, United States
- Eden Medical Center — Castro Valley, California, United States
- Valley Medical Oncology Consultants - Castro Valley — Castro Valley, California, United States
- Valley Medical Oncology — Fremont, California, United States
- Cancer Care Associates — Fresno, California, United States
- Glendale Memorial Hospital Comprehensive Cancer Center — Glendale, California, United States
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Contra Costa Regional Medical Center — Martinez, California, United States
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP — Marysville, California, United States
- Community Hospital of the Monterey Peninsula Comprehensive Cancer Center — Monterey, California, United States
- Camino Medical Group - Treatment Center — Mountain View, California, United States
- El Camino Hospital Cancer Center — Mountain View, California, United States
- Highland General Hospital — Oakland, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- Bay Area Breast Surgeons, Incorporated — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Larry G Strieff MD Medical Corporation — Oakland, California, United States
- Tom K Lee, Incorporated — Oakland, California, United States
- Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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