The Timing of Prophylactic Antibiotics in Cesarean Section and the Risk of Post-operative Febrile Morbidity

Stopped early · Phase 4

Conditions studied: Cesarean Section

In brief

The purpose of this study is to determine whether the timing of prophylactic antibiotic administration for cesarean section (immediate preoperative versus intraoperative administration) impacts the rate of postoperative febrile morbidity. The specific aim of the project is to test the hypothesis that preoperative antibiotic administration will decrease the rate of composite postoperative febrile morbidity.

Key facts

Study ID

NCT00133029

Run by

University of Pennsylvania

Starts

2004-07-01

Expected to finish

2006-07-01

Last updated by the study team

2016-08-15

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Gestational age > 36 weeks
• Ability to understand requirements of the study
• Elective/non-emergent cesarean section selected as route of delivery by treating physicians

You may not qualify if…

• Known fetal anomaly
• Exposure to antibiotics within 7 days of admission, including intrapartum group B streptococcal (GBS) prophylaxis
• Emergent cesarean delivery (i.e. for fetal distress, maternal distress, obstetric hemorrhage)
• Overt maternal intrapartum infection requiring antibiotics
• Prolonged rupture of membranes (>18 hours)

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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