Impact of Smoking Cessation on Sleep - 5

Completed · Phase 4 · Has a placebo group

Conditions studied: Tobacco Use Cessation, Sleep Disorders

In brief

Smoking is a major health problem with a direct link to elevated heart- and lung-related problems. Nicotine is highly addictive, which makes quitting difficult and relapse after quitting highly probable. Any type of sleep disturbance may make quitting even harder. The purpose of this study is to evaluate the effect of bupropion and nicotine replacement therapies (NRT) on sleep disturbances. In turn, this might show how such medications affect attempts at smoking cessation.

Key facts

Study ID

NCT00132821

Run by

National Institute on Drug Abuse (NIDA)

People needed

59

Starts

2005-08-01

Expected to finish

2009-05-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Meets DSM-IV criteria for nicotine dependence
• History of smoking at least 20 cigarettes each day for 2 years prior to enrollment
• Expired carbon monoxide level of at least 10 ppm
• Body mass index less than 30 kg/m2

You may not qualify if…

• Meets DSM-IV criteria for dependence on substances other than nicotine and caffeine
• Substance abuse within the year prior to enrollment
• History of DSM-IV diagnosis of schizophrenia, bipolar disorder, obsessive compulsive disorder, or chronic depression
• Current diagnosis of major depression
• History of neurological illness or trauma (e.g., stroke, seizure disorder, febrile seizures, electroconvulsive therapy)
• Family history of seizure disorder
• History of head injury with loss of consciousness for longer than 1 hour
• Currently diagnosed with a sleep disorder
• Currently diagnosed with anorexia or bulimia
• Severe or chronic cardiovascular, lung, kidney, or neurological disease
• Uncontrolled hypertension or diabetes
• Use of medications contraindicated with bupropion
• High frequency alcohol use or binge drinking in the month prior to enrollment
• Pregnant or breastfeeding

Where it is running

• SRI International — Menlo Park, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.