Multicenter Uveitis Steroid Treatment (MUST) Trial

Completed · Phase 4

Conditions studied: Uveitis

In brief

The purpose of this study is to compare the effectiveness of standardized systemic therapy versus fluocinolone acetonide implant therapy for the treatment of severe cases of non-infectious intermediate uveitis, posterior uveitis, or panuveitis.

Key facts

Study ID

NCT00132691

Run by

JHSPH Center for Clinical Trials

People needed

255

Starts

2005-09-01

Expected to finish

2010-12-01

Last updated by the study team

2016-11-25

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 13 years or older
• Best-corrected visual acuity of hand motions or better in at least one eye with uveitis
• Intraocular pressure 24 mm Hg or less in all eyes with uveitis

You may not qualify if…

• Inadequately controlled diabetes
• Uncontrolled glaucoma
• Advanced glaucomatous optic nerve injury
• A history of scleritis; presence of an ocular toxoplasmosis scar.
• HIV infection or other immunodeficiency disease for which corticosteroid therapy would be contraindicated according to best medical judgment

Where it is running

• Jacobs Retina Center, UCSD — La Jolla, California, United States
• Doheny Eye Institute, USC — Los Angeles, California, United States
• Jules Stein Eye Institute, UCLA — Los Angeles, California, United States
• Proctor Foundation, UCSF — San Francisco, California, United States
• Anne Bates Leach Eye Hospital, University of Miami Miller School of Medicine — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• University of Illinois at Chicago Eye Center — Chicago, Illinois, United States
• Wilmer Eye Institute, Johns Hopkins University — Baltimore, Maryland, United States
• National Eye Institute, NIH — Bethesda, Maryland, United States
• Massachusetts Eye Research & Surgery Institute — Cambridge, Massachusetts, United States
• Kellogg Eye Center, University of Michigan — Ann Arbor, Michigan, United States
• Barnes Retina Institute — St Louis, Missouri, United States
• New York Eye and Ear Infirmary — New York, New York, United States
• Duke Eye Center, Duke University — Durham, North Carolina, United States
• Scheie Eye Institute, University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Texas Retina Associates — Dallas, Texas, United States
• Vitreoretinal Consultants — Houston, Texas, United States
• John A. Moran Eye Center, University of Utah — Salt Lake City, Utah, United States
• Virginia Eye Consultants — Norfolk, Virginia, United States
• Royal Victoria Eye & Ear Hospital — East Melbourne, Australia
• United Kingdom Institute of Ophthalmology — London, United Kingdom

Full record on ClinicalTrials.gov

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