A Phase 1 Open-Label Study of E7974 Administered on Days 1 and 15 of a 28-Day Cycle in Patients With Solid Malignancies

Completed · Phase 1 · Has a placebo group

Conditions studied: Cancer, Malignant Tumors

In brief

The purpose of this study is to determine the maximum tolerated dose (MTD) of E7974 administered on Days 1 and 15 of a 28-day cycle in subjects with solid malignancies that have progressed following effective therapy or for which no effective therapy exists.

Key facts

Study ID

NCT00130169

Run by

Eisai Inc.

People needed

30

Starts

2006-01-01

Expected to finish

2009-08-01

Last updated by the study team

2015-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who meet all of the inclusion criteria and none of the exclusion criteria will be eligible for entry into the study:
• Patients must have a pathologically diagnosed, histologically or cytologically confirmed solid malignancy that has progressed following effective therapy or for which no effective therapy exists (including surgery or radiation therapy).
• Patients must be >= 18 years of age.
• Patients must have an Eastern Cooperative Oncology Group (ECOG) status of 0, 1 or 2.
• Patients must have a life expectancy of >= 3 months.
• Patients must have adequate renal function as evidenced by serum creatinine <= 1.5 mg/dL or creatinine clearance >= 40 mL/minute (min)
• Patients must have adequate bone marrow function as evidenced by absolute neutrophil count >= 1,200/µL, hemoglobin of >= 9 g/dL (may be transfused), and platelet count (not transfused) >= 100,000/µL.
• Patients must have adequate liver function as evidenced by bilirubin <= 1.5 mg/dL and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <= 3 times the upper limits of normal (ULN), unless related to liver involvement by tumor, in which case <= 5.0 times ULN.
• Patients must be willing and able to sign written informed consent and be able to comply with the study protocol for the duration of the study.
• Patients must be willing and able to undergo blood draw and urine sampling for PK in Cycle 1.
• Patients may have either measurable or non-measurable disease.
• For Prostate Cancer patients only being enrolled at the MTD expansion phase:
• Males with histologically proven adenocarcinoma of the prostate that has progressed (i.e. a minimum of three successive baseline values to document two consecutive rises in Prostate Specific Antigen (PSA) (with the last value 5 ng/mL) taken at least one week apart prior to study entry) despite castration or maintenance of castrate-level testosterone (defined as serum testosterone 50 ng/dL or 1.7 nmol/L), during non-hormonal chemotherapy.
• Patients must have failed at least one previous chemotherapeutic regimen with tubulin binding agents such as docetaxel.
• Exclusion Criteria:The presence of one or more of the following criteria will disqualify a patient from enrollment in the study:
• Patients who have received chemotherapy within three weeks of E7974 treatment start (6 weeks for a nitrosourea).
• Patients who have not recovered from any chemotherapy-related or other therapy-related toxicity to <= Grade 1 at study entry (excluding Grade 2 alopecia).
• Patients who have received radiotherapy <= 3 weeks prior to study enrollment, whose marrow exposure has exceeded 25% and who have not recovered from the toxic effects of the treatment prior to study enrollment (except for alopecia).
• Patients who have had major surgery without full recovery or major surgery within three weeks of E7974 treatment start.
• Patients with primary brain tumors or metastasis at study entry must have controlled them for >= 1 month by previous treatment, including radiation therapy and corticosteroids.
• Women who are pregnant or breastfeeding.
• Women of childbearing potential with either a positive serum pregnancy test at screening or no pregnancy test.
• Women of childbearing potential unless (1) surgically sterile, (2) physiologically postmenopausal for >= 12 months, or (3) using adequate measures (including barrier methods) of contraception.
• Fertile men or their partners who are not willing to use contraception.
• Patients who have a history of positive testing for Human Immunodeficiency Virus (HIV) and/or have active hepatitis B or active hepatitis C at study entry.

Where it is running

• Nevada Cancer Institute — Las Vegas, Nevada, United States
• University Hospital Medical Center - SUNY at Stony Brook — Stony Brook, New York, United States

Full record on ClinicalTrials.gov

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