Study Evaluating the Effect of Sirolimus on Non-Melanoma Skin Cancer in Kidney Transplant Recipients

Completed · Phase 4

Conditions studied: Skin Neoplasms, Kidney Transplantation

In brief

The purpose of this study is to determine the effect of sirolimus on the prevention of new non-melanoma skin cancer (NMSC) in kidney transplant recipients.

Key facts

Study ID

NCT00129961

Run by

Wyeth is now a wholly owned subsidiary of Pfizer

People needed

86

Starts

2005-08-01

Expected to finish

2009-01-01

Last updated by the study team

2012-04-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Kidney transplant at least 1 year prior
• Subjects with a functioning renal allograft with calculated glomerular filtration rate (GFR) ≥40mL/min (Nankivell method) and proteinuria ≤500mg/day.
• Stable on cyclosporine or tacrolimus-based multi-drug immunosuppressive regimen
• History of NMSC within last 3 years

You may not qualify if…

• History of other cancer within last 3 years
• NMSC with metastatic disease or more than 20 NMSC lesions in last 12 months
• Multiple organ transplant

Where it is running

• Study site — San Diego, California, United States
• Study site — San Francisco, California, United States
• Study site — Gainesville, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Chicago, Illinois, United States
• Study site — Durham, North Carolina, United States
• Study site — Cincinnati, Ohio, United States
• Study site — Portland, Oregon, United States
• Study site — Philadelphia, Pennsylvania, United States
• Study site — Charleston, South Carolina, United States
• Study site — Nashville, Tennessee, United States
• Study site — Madison, Wisconsin, United States
• Study site — Camperdown, New South Wales, Australia
• Study site — Wooloongabba, Queensland, Australia
• Study site — Woodville, South Australia, Australia
• Study site — Adelaide, Australia
• Study site — Clayton, Australia
• Study site — Herston, Australia
• Study site — Parkville, Australia
• Study site — Randwick, Australia
• Study site — Westmead, Australia
• Study site — Vancouver, British Columbia, Canada
• Study site — Grafton, Auckland, New Zealand

Full record on ClinicalTrials.gov

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