Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
Completed · Phase 2 · Has a placebo group
Conditions studied: Tobacco Use Cessation, Tobacco Use Disorder
In brief
Little is known about the best ways to help young people stop smoking. Bupropion (a medication marketed as Wellbutrin or Zyban) has proved helpful in treating adult smokers. The purpose of this study is to determine if bupropion is also effective in treating smokers between the ages of 12 and 25 years old. This study also compares the effectiveness of bupropion used as a supplement to behavioral treatment versus behavioral treatment used alone. In addition, the study evaluates whether hormonal response to stress measured prior to the start of treatment predicts whether individuals respond well to treatment with medication.
Key facts
- Study ID
- NCT00129272
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 172
- Starts
- 2004-05-01
- Expected to finish
- 2011-01-01
- Last updated by the study team
- 2017-05-22
Who can join
Age: 12 and older, up to 25. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Has smoked at least 10 cigarettes each day for 3 or more months
- Weighs at least 90 lbs
- Motivated to quit smoking and has had at least one previous failed attempt
- Speaks, reads, and writes English
- Either diagnosed as depressed OR no history of a psychiatric disorder
You may not qualify if…
- History of bipolar disorder, eating disorder, schizophrenia, schizoaffective disorder, autism, or non-nicotine substance use disorder in the 6 months prior to study entry
- Currently suicidal or with a history of a suicide attempt in the 6 months prior to study entry
- Psychotic symptoms
- Use of psychotropic medication(s)
- Serious medical condition
- Prior use of bupropion for smoking cessation
- Currently using other smoking cessation treatments
Where it is running
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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