Ketoconazole Administration: How it is Affected by the Body and Broken Down and How it Acts on the Body When Used With Velcade

Completed · Phase 1

Conditions studied: Tumors

In brief

The purpose of this study is to investigate how ketoconazole (Nizoral) affects the pharmacokinetics (how the study drug is affected by the body and broken down) and pharmacodynamics (how the study drug acts on the body) of the active ingredient in the study drug Velcade (bortezomib).

Key facts

Study ID

NCT00129207

Run by

Millennium Pharmaceuticals, Inc.

Last updated by the study team

2008-02-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients 18 years of age or older, with a diagnosis of advanced solid tumor for which no curative or other treatment of higher priority is available
• Karnofsky Performance Status (KPS) equal to or greater than 70%
• Normal liver function tests (aspartate transaminase [AST] or alanine transaminase [ALT] equal to or less than 2 x upper limit of normal [ULN])
• Total bilirubin equal to or less than 1.5 x ULN
• Calculated creatinine clearance equal to or greater than 50 mL/min
• Normal serum calcium

You may not qualify if…

• Patients with significant cardiac disease
• Equal to or greater than Grade 2 neuropathy
• Active hepatitis
• HIV infection
• Secondary malignancy
• Transfusion-dependent or received extensive radiation therapy, systemic chemotherapy, or other antineoplastic therapy within 4 weeks of enrollment
• Patients taking concomitant medications having inhibitory or inducing activity for CYP 3A4

Where it is running

• Medical Center, UPMC Cancer Pavilion — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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