Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery

Completed · Phase 4

Conditions studied: Atrial Fibrillation

In brief

The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following non-cardiac open-chest surgery. Their specific aims are to: * Determine the effectiveness of amiodarone for the prevention of AF following non-cardiac open-chest surgery; * Determine the influence of the prevention of AF following non-cardiac thoracic surgery on post-surgical duration of stay in the Intensive Care Unit (ICU); post-surgical duration of stay in a hospital unit that employs cardiac monitoring; and duration of post-surgical hospital stay; and * Determine the safety of amiodarone for the prevention of AF following non-cardiac open-chest surgery.

Key facts

Study ID

NCT00127712

Run by

Indiana University

People needed

130

Starts

2004-09-01

Expected to finish

2008-02-01

Last updated by the study team

2013-09-18

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females over the age of 40
• Scheduled to undergo pneumonectomy or lobectomy

You may not qualify if…

• History (hx) of atrial fibrillation
• Prior severe side effects from amiodarone
• Elevated liver enzymes >3 times the upper limit of normal (UNL)
• QTc interval > 450 ms
• Receiving class Ia or class III antiarrhythmics

Where it is running

• Indiana University — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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