Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury

Completed · Not applicable

Conditions studied: Acute Lung Injury, Acute Respiratory Distress Syndrome

In brief

The purpose of this study is to see whether esophageal pressure (PES) measurements will allow the investigators to choose the best method of mechanical ventilation in patients with acute lung injury (ALI).

Key facts

Study ID

NCT00127491

Run by

Beth Israel Deaconess Medical Center

People needed

63

Starts

2004-05-01

Expected to finish

2010-05-01

Last updated by the study team

2017-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with ALI/ARDS according to the International Consensus Conference criteria:
• PaO2/FiO2 ratio < 300
• Acute onset
• Bilateral infiltrates on chest radiography
• PAOP < 18 or, in patients without a pulmonary artery catheter, no other evidence of abnormal cardiac function

You may not qualify if…

• Patients with esophageal varices
• Patients with esophageal trauma
• Patients with recent esophageal surgery
• Patients with coagulopathy (platelets < 80k or International Normalized Ratio [INR]> 2 )
• Post transplant patients
• Patients with significant broncho-pleural fistula

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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