A Medication Trial Combined With Behavior Therapy for Individuals With Obsessive-compulsive Disorder

Completed · Not applicable

Conditions studied: Obsessive-Compulsive Disorder

In brief

This study examines the efficacy of the medication D-Cycloserine in the reduction of obsessions and compulsions in individuals with obsessive-compulsive disorder (OCD). All study participants will receive Exposure and Response Prevention, a common form of behavior therapy for individuals with OCD. Half (50%) of the participants will be randomly assigned to the placebo condition and the other half (50%) will be randomly assigned to receive D-Cycloserine. Because all participants will receive 10 sessions of behavior therapy, all participants are expected to improve from this treatment.

Key facts

Study ID

NCT00126282

Run by

Massachusetts General Hospital

People needed

50

Starts

2003-12-01

Expected to finish

2007-12-01

Last updated by the study team

2009-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets diagnosis for obsessive-compulsive disorder

You may not qualify if…

• History of psychotic disorders
• History of neurological disorders
• History of bipolar disorders

Where it is running

• Anxiety Disorders Center, The Institute of Living — Hartford, Connecticut, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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