The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression

Completed · Phase 3 · Has a placebo group

Conditions studied: Depression, Major Depressive Disorder, Unipolar Depression

In brief

Many people with depression are treated with a serotonin-specific reuptake inhibitor anti-depressant (SSRI) and feel 'better'. Although many people feel 'better', they do not feel completely 'well'. Often, individuals continue to complain of cognitive problems such as lack of attention, diminished motivation, and impaired problem-solving. This study looks at whether residual and cognitive symptoms of depression in individuals are affected by the addition of Wellbutrin (bupropion).

Key facts

Study ID

NCT00125957

Run by

Mclean Hospital

People needed

32

Starts

2005-08-01

Expected to finish

2011-12-01

Last updated by the study team

2014-08-06

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Depression
• SSRI-treated

You may not qualify if…

• Bipolar disorder
• Serotonin-norepinephrine reuptake inhibitor (SNRI) or bupropion treatment
• Treatment-resistant depression
• Seizure disorder
• Bulimia or anorexia nervosa
• Pregnancy

Where it is running

• McLean Hospital — Belmont, Massachusetts, United States

Full record on ClinicalTrials.gov

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