Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure: (UNLOAD)
Completed · Not applicable
Conditions studied: Congestive Heart Failure
In brief
The purpose of this study is to compare patients who are suffering from heart failure and who are fluid overloaded to determine if ultrafiltration (UF) can remove more of the extra fluid as measured by weight loss while in the hospital and improve the patient's breathing.
Key facts
- Study ID
- NCT00124137
- Run by
- Nuwellis, Inc.
- People needed
- 200
- Starts
- 2004-04-01
- Expected to finish
- 2005-10-01
- Last updated by the study team
- 2007-03-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients hospitalized with primary diagnosis of acute decompensated congestive heart failure (adCHF)
- Evidence of fluid overload as indicated by:
- pitting edema (2+) of lower extremities;
- jugular venous distension;
- pulmonary edema or pleural effusion;
- ascites;
- paroxysmal nocturnal dyspnea or 2-pillow orthopnea
You may not qualify if…
- Acute coronary syndrome
- Creatinine greater than 3.0
- Systolic blood pressure less than or equal to 90 mmHg
- Hematocrit greater than 45%
- Prior administration of IV vasoactive drugs in the emergency room (ER)
- Clinical instability requiring pressors during hospitalization
- Recent use of iodinated contrast material
- Severe concomitant disease expected to prolong hospitalization
- Sepsis
- On or requires renal dialysis
- Had a cardiac transplant
- Heparin allergy
Where it is running
- Midwest Heart Institute — Lombard, Illinois, United States
Full record on ClinicalTrials.gov
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