Fish Oil for the Treatment of Depression in Patients With Multiple Sclerosis

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Multiple Sclerosis, Depression

In brief

This study will determine whether fish oil can reduce depression in people with multiple sclerosis (MS) who are mild to moderately depressed and are currently taking antidepressant medication. Study hypothesis: Three months of fish oil supplementation will improve depression scores on the Montgomery-Asberg depression rating scale (MADRS) or Beck Depression Inventory (BDI) better than placebo.

Key facts

Study ID

NCT00122954

Run by

Oregon Health and Science University

People needed

39

Starts

2005-07-01

Expected to finish

2009-06-01

Last updated by the study team

2017-06-08

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of relapsing-remitting MS
• Diagnosis of depressive disorder
• Score between 11 and 30 on the Montgomery-Asberg Depression Rating Scale (MADRS)
• Score of 25 or greater on the Mini-Mental State Examination (MMSE)
• Currently taking antidepressant medication for at least 3 months prior to study entry

You may not qualify if…

• Currently taking fatty acid supplements
• Consume more than 6 oz of fish per week within 1 month prior to study entry
• Severe depression
• Suicidal thoughts
• Other psychological disorders
• Currently taking more than two types of antidepressants
• Any serious medical condition that would interfere with the study
• Worsening of MS symptoms or corticosteroid treatment within 1 month prior to study entry
• Current enrollment in another fish oil study
• Pregnancy

Where it is running

• Oregon Health and Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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