Perioperative Inflammation and Cyclooxygenase 2 (COX-2)

Completed · Phase 4

Conditions studied: Neurosurgery, Pain

In brief

Surgery initiates a complex cascade of events involving the release of chemical compounds from nerve endings and damaged tissue which leads to an inflammatory and pain response. The purpose of this investigation is to measure various chemical mediators in the blood and cerebrospinal fluid, and to test the hypothesis that they will be decreased in patients treated with a COX-2 inhibitor.

Key facts

Study ID

NCT00122096

Run by

University of Washington

People needed

30

Starts

2002-11-01

Expected to finish

2006-01-01

Last updated by the study team

2008-09-26

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing surgery requiring lumbar drain placement

You may not qualify if…

• Contraindication to COX-2 inhibitor (renal or hepatic insufficiency)
• Known adverse reaction to nonsteroidal anti-inflammatory drugs (NSAIDs)
• Use of NSAID or COX-2 within 7 days prior to surgery

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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